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Components of COVID-19 vaccines authorized by Health Canada

Download in PDF format 123 KB, 3 pages)Organization: Public Health Agency of Canada Published: 2021-05-07

Ingredients in the Pfizer-BioNTech COVID-19 vaccineComponentFunctionKnown to be a potential allergenMessenger RNA (mRNA)Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2Active ingredient:

  • Genetic code that provides the blueprint for our body's cells to make the SARS-CoV-2 spike protein in the cytoplasm, which is then displayed on the cell surface and elicits an immune response

NoComponents of the lipid nanoparticle that delivers the mRNA into the cellALC-0159 = 2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide

  • Forms a protective layer that stabilizes the nanoparticle, improves storage stability and reduces non-specific binding to proteins

Yes: Polyethylene glycol (PEG) can be an allergen1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)

  • Part of the double layer of lipids (lipid bilayer) that forms the nanoparticle

NoCholesterol

  • Provides structural support for the lipid bilayer of the nanoparticle and supports mobility of lipid components

NoALC-0315 = (4-hydroxybutyl) azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)

  • Main ingredient in the lipid-nanoparticle that delivers the mRNA into the cell

  • Cationic (positively charged) lipid that during the manufacturing process, promotes the nanoparticle to assemble into a virus size particle with the negatively charged mRNA in the middle, and facilitates mRNA release from the nanoparticle once inside the cell

NoAdditional ingredientsPotassium chloride

  • Salt that forms a buffer to balance the pH (acidity) of the vaccine

NoMonobasic potassium phosphate

  • Salt that forms a buffer to balance the pH (acidity) of the vaccine

NoSodium chloride

  • Salt that forms a buffer to balance the pH (acidity) of the vaccine

NoDibasic sodium phosphate dehydrate

  • Salt that forms a buffer to balance the pH (acidity) of the vaccine

NoSucrose

  • Sugar to protect and stabilize the vaccine during freezing and prevent the particles from sticking together

NoNormal saline (provided separately from the vaccine)

  • Water and salt solution added as the diluent to the vaccine

NoNotes: Does not contain latex in the stopper

Ingredients in the COVID-19 vaccine ModernaComponentFunctionKnown to be a potential allergenMessenger RNA (mRNA)Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2Active ingredient:

  • Genetic code that provides the blueprint for our body's cells to make the SARS-CoV-2 spike protein in the cytoplasm, which is then displayed on the cell surface and elicits an immune response

NoComponents of the lipid nanoparticle that delivers the mRNA into the cellPolyethylene glycol (PEG) 2000 DMG

  • Serves to stabilize and prolong the lifespan of the nanoparticle

Yes: Polyethylene glycol (PEG) can be an allergen1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)

  • Part of the double layer of lipids (lipid bilayer) that forms the nanoparticle

NoCholesterol

  • Provides structural support for the lipid bilayer of the nanoparticle and supports mobility of lipid components

NoLipid SM-102

  • Ionizable lipid that interacts with mRNA

  • During the manufacturing process, promotes the nanoparticle to assemble into a virus size particle with the negatively charged mRNA in the middle and facilitates mRNA release from the nanoparticle once in the cell

NoAdditional ingredientsTromethamine

  • Base that forms a buffer and works to balance the pH (acidity) of the vaccine

  • Salt that forms a buffer and works to balance the pH (acidity) of the vaccine

  • Acid that forms a buffer to balance the pH (acidity) of the vaccine

NoSodium acetate

  • Salt that forms a buffer to balance the pH (acidity) of the vaccine

  • Helps to stabilize the particle

NoSucrose

  • Sugar to protect and stabilize the vaccine during freezing and prevent the particles from sticking together

NoNote: Does not contain latex in the stopper

Ingredients in the AstraZeneca COVID-19 vaccineComponentFunctionKnown to be a potential allergenSources of genetic code for spike proteinModified adenovirus (ChAdOx1) containing spike protein genetic codeActive ingredient:

  • Adenovirus that has been genetically modified to not replicate and to carry the gene for the spike protein of the SARS-CoV-2 virus

  • Delivers genetic code of the spike protein to the nucleus of the body's cell where mRNA is made and transported to the cytoplasm of the body's cell where the spike protein is then made, displayed on the cell surface and elicits an immune response

NoAdditional ingredientsL-Histidine

  • Buffering agent: pH (acidity) control and stability during storage

NoL-Histidine hydrochloride monohydrate

  • Buffering agent: pH (acidity) control and stability during storage

NoMagnesium chloride hexahydrate

  • Stabilizer: protects the vaccine from adverse conditions (electrostatic interactions)

NoPolysorbate 80

  • Surfactant: stabilizes the adenovirus by reducing virus sticking to surfaces and minimizing interactions where the liquid vaccine comes into contact with air

  • Stabilizer: protects the vaccine from adverse conditions (prevents free-radical induced oxidation of the adenovirus)

NoSucrose

  • Cryo-protectant: stabilizes the adenovirus during freezing and thawing, enhances the adenovirus' ability to withstand temperature changes, and acts as a tonicity agent

NoSodium chloride

  • Cryo-protectant: stabilizes the adenovirus during freezing and thawing and acts as a tonicity agent

NoDisodium edetate dihydrate (EDTA)

  • Stabilizer: protects the vaccine from adverse conditions (prevents free-radical induced oxidation of the adenovirus)

NoWater

  • Liquid in the vaccine vial

NoNote: Does not contain latex in the stopper

 
 
 

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